High-resolution analysis of the pneumococcal transcriptome under a wide range of infection-relevant conditions

Rieza Aprianto, Jelle Slager, Siger Holsappel and Jan-Willem Veening
bioRxiv 2018

Expression Value
rlog TPM log2TPM
Graph Height
200 400 600 800
Graph Width
600 800 1000 1200
Select Condition
Nose (NMC) Trans, 5 min Trans, 60 min Trans>>NMC NMC>>LMC Lung (LMC) NMC>>BMC Blood (BMC) BMC>>C+Y NMC>>CSFMC CSF (CSFMC)
Fever C+Y>>NMC C+Y CSP, 3 min CSP, 10 min CSP, 20 min Infect, 0 mpi Infect, 30 mpi Infect, 60 mpi Infect, 120 mpi Infect, 240 mpi
Table Orientation
Wide Long
If none is selected ALL will be displayed
Color Scale

Selected Genes
Pneumococcal Genes

Nose (NMC) NEPGrowth in nose-like medium
Trans, 5 minNT5Growth in nose-like medium, transmission 5 min
Trans, 60 minNT60Growth in nose-like medium, transmission 60 min
Trans>>NMCNTNGrowth in nose-like medium, trans. 5 min, to nose-like medium 5 min
NMC>>LMCN>>LGrowth in nose-like medium , in lung-like medium 5 min
Lung (LMC) LEPGrowth in lung-like medium
NMC>>BMCN>>BGrowth in nose-like medium, in blood-like medium 5 min
Blood (BMC)BEPGrowth in blood-like medium
BMC>>C+YB>>CGrowth in blood-like medium, in C+Y 5 min
NMC>>CSFMCN>>FGrowth in nose-like medium, in CSF-like medium 5 min
CSF (CSFMC)FEPGrowth in CSF-like medium
FeverF40Growth in CSF-like medium, then 40℃ (fever-like) 5 min
C+Y>>NMC C>>NGrowth in C+Y, in nose-like medium 5 min
C+YCEPGrowth in C+Y
CSP, 3 minC03Growth in C+Y, CSP 3 min
CSP, 10 minC10Growth in C+Y, CSP 10 min
CSP, 20 minC20Growth in C+Y, CSP 20 min
Infect, 0 mpiI00Co-incubation with A549, 0 minutes post infection
Infect, 30 mpiI30Co-incubation with A549, 30 minutes post infection
Infect, 60 mpiI60Co-incubation with A549, 60 minutes post infection
Infect, 120 mpiI120Co-incubation with A549, 120 minutes post infection
Infect, 240 mpiI240Co-incubation with A549, 240 minutes post infection

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